ADVOCATE for hunde
Advokat eliminerer lopper og loppe larver, hjerteorm, hageorm, rundorm og øre mider.
Advokat eliminerer lopper og loppe larver, hjerteorm, hageorm, rundorm og øre mider.
- behandling og forebyggelse af lopper Ctenocephalides spp. Reducerer forekomsten af loppe allergi Dermatitis. Larve loppe faser er dræbt i omgivelser af advokat behandlet kæledyr.
- forebyggelse af hjerteorm Dirofilaria immitis infektion.
- behandling og kontrol af rundorm Toxocara cati, Toxascaris leonina herunder larve (L4) og umoden voksen faser
Til behandling og kontrol af:
- Piskeorm Trichuris vulpis
- hageorm Ancylostoma tubae-forme, Ancylostoma brazilense, Uncinaria stenocepala, herunder larve (L4) og umoden voksen faser af alle arter.
- generaliseret infektioner med Demodex Demodex canis.
- scarcoptic sukkerærter Sarcoptes scabieJeg.
- øre mider Otodectes cynotis.
- lus
LOPPE kontrol og forebyggelse - advokat har vist sig at dræbe voksne og larver lopper inden for 20 minutter af kontakt ved optagelse via loppe intersegmental membraner. Stopper lopper fra fodring i 3-5 minutter. Lopper er ikke forpligtet til at bide dyret for at modtage en dødelig dosis. Den efterfølgende fodring aktivitetaf lopper på kæledyr kan fremkalde en overfølsomhed hudlidelse kaldet loppe allergi dermatitis (FAD). Behandling af kæledyr med advokat hurtigt få has på lopper og reducerer forekomsten af denne betingelse. Advokat kan bruges som det eneste produkt til loppe kontrol som det bryder lide cyklus og dræber lopper emerfinf Frima miljø til reinfest katten. Hurtigere løsning af tunge miljømæssige parasitære kan opnås ved yderligere miljømæssige kontrolforanstaltninger ved hjælp af en passende registreret produkt.
HEATWORM forebyggelse - behandling med ADVOCATE bør starte en måned før den første eksponering for myg. ADVOKAT skal anvendes på en måned intervaller i løbet af året når myg (som bære og overføre heartworm larver) er til stede. I mange områder af Australien kontinuerlig, er året rundt heartworm forebyggelse anbefalet. For at etablere en rutine, anbefales det, at den samme dag eller dato bruges hver måned til at administrere fortaler. Når du erstatter en anden heartworm forebyggende produkt, skal den første behandling med ADVOCATE gives senest en måned efter den sidste dosis af det forrige produkt.
ORMEN kontrol - fortaler behandler og styrer de store mave nematoder af hunde men kontrollerer ikke bændelorm. For at kontrollere bruge disse orme DRONTAL eller DRONCIT som passende. Hunde kan blive reinfested med orme, men regelmæssig brug af advokat vil fjerne dem. Hvis ormen stadig problemer konsultere din dyrlæge.
BEHANDLING OG KONTROLØRE MIDER - til behandling og kontrol af øre mites er advokat meget virkningsfuldt som en enkelt dosis. Månedlig anvendelse af generaladvokat med kontrol nogen efterfølgende øret mide angreb.
HVALPE-kan behandles med advokat fra 7 uger gammel. Hvalpe skal være ormekur på 2,4 og 8 ugens i alder.
Advocate Hund
Advocate Hund may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Ingredient matches for Advocate Hund
Imidacloprid
Imidacloprid is reported as an ingredient of Advocate Hund in the following countries:
Moxidectin
Moxidectin is reported as an ingredient of Advocate Hund in the following countries:
Important Notice: The Drugs.com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
Drugs.com Mobile Apps
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.
About
Terms & Privacy
Subscribe to receive email notifications whenever new articles are published.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Jan 31st, 2018), Cerner Multum™ (updated Feb 2nd, 2018), Wolters Kluwer™ (updated Feb 2nd, 2018) and others. To view content sources and attributions, please refer to our editorial policy.
We comply with the HONcode standard for trustworthy health information - verify here
Advocate Hund
Here is the some steps to help you to save money on Advocate Hund purchase.
Read drug prescription
Advocate Hund uses
DESCRIPTION:
Advocate Hund is a chloronicotinyl nitroguanidine insecticide. The chemical name of Advocate Hund is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. The chemical name of moxidectin is [6R, 23E, 25S(E)]-5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino) milbemycin B.
INDICATIONS:
Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight.
HUMAN WARNINGS:
Children should not come in contact with the application site for 30 minutes after application.
Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Wash hands thoroughly with soap and warm water after handling.
If contact with eyes occurs, hold eyelids open and flush with copious amounts of water for 15 minutes. If eye irritation develops or persists, contact a physician. If swallowed, call poison control center or physician immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or physician. People with known hypersensitivity to benzyl alcohol, Advocate Hund or moxidectin should administer the product with caution. In case of allergic reaction, contact a physician. If contact with skin or clothing occurs, take off contaminated clothing. Wash skin immediately with plenty of soap and water. Call a poison control center or physician for treatment advice.
The Safety Data Sheet (SDS) provides additional occupational safety information. For a copy of the Safety Data Sheet (SDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. For consumer questions call 1-800-255-6826.
PRECAUTIONS:
Avoid oral ingestion. Cats may experience hypersalivation, tremors, vomiting and decreased appetite if Advantage Multi for Cats is inadvertently administered orally or through grooming/licking of the application site.
The safety of Advantage Multi for Cats has not been established in breeding, pregnant, or lactating cats.
The effectiveness of Advantage Multi for Cats against heartworm infections (D. immitis) after bathing has not been evaluated in cats.
Use of this product in geriatric patients with subclinical conditions has not been adequately studied. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.
(See ADVERSE REACTIONS.)
ADVERSE REACTIONS:
Lethargy (protracted sleeping,
3 cats These three cats were from the same household and included one 13-yr-old cat in good health, one 15-yr-old FIV positive cat in good health, and one 15-yr-old, underweight cat in fair health. Lethargy was noted for 24 to 36 hrs after the first treatment only; one cat was unsteady at 48 hrs. These cats were not on other medications. (2.7%)
Behavioral changes (e.g., agitated, excessive
grooming, hiding, pacing, spinning)
Discomfort (e.g., scratching, rubbing,
Hypersalivation (within 1 hour after
Coughing and gagging
During another field study, a 16-year-old cat with renal disease slept in the same place without moving for two days following application.
Laboratory Effectiveness Studies: Advantage Multi for Cats was administered at the recommended dose to 215 cats in 20 effectiveness studies. One random-sourced cat exhibited signs consistent with either moxidectin toxicity or viral respiratory disease and died 26 hours after product application; necropsy findings were inconclusive as to the cause of death. A second cat that became ill 3 days after application of Advantage Multi for Cats responded to treatment for respiratory infection and completed the study. A third cat became ill on day 3 and died with signs and lesions attributable to panleukopenia on day 7 after moxidectin application.
Post-Approval Experience: The following adverse events are based on post-approval adverse drug experience reporting. Not all adverse reactions are reported to FDA CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. The following adverse events in cats are listed in decreasing order of reporting frequency: hypersalivation, depression/lethargy, application site reactions (alopecia, pruritus, lesions, and erythema), decreased appetite, vomiting, hyperactivity, ataxia, trembling, and behavior disorder (hiding).
In some cases death has been reported.
In humans, ocular and dermal irritation, nausea, numbness or tingling of the mouth and lips, anaphylaxis, pruritus, vomiting, and tongue/taste abnormalities have been reported following exposure to this product.
To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Bayer Animal Health at 1-800-422-9874.
For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.
DOSAGE AND ADMINISTRATION:
Do not apply to irritated skin.
1. Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Advantage Multi for Cats tube that correctly corresponds with the body weight of the cat.
9.1–18 Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi for Cats tubes.
2. While holding the tube in an upright position, remove the cap from the tube.
3. Turn the cap over and push the other end of cap onto the tip of the tube.
4. Twist the cap to break the seal and then remove cap from the tube.
5. Part the hair on the back of the cat’s neck at the base of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift tube away from skin before releasing pressure on tube.
Do not get this product in the cat’s mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.
Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Cats should be administered at one-month intervals. Advantage Multi for Cats may be administered year-around or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Cats immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Cats should be given within one month of the last dose of the former medication. At the discretion of the veterinarian, cats older than 6 months of age may be tested to determine the presence of existing heartworm infection before treatment with Advantage Multi for Cats (See ADVERSE REACTIONS – Post-Approval Experience).
Flea Treatment: For the treatment of flea infestations, Advantage Multi for Cats should be administered at one-month intervals. If the cat is already infested with fleas when the first dose of Advantage Multi for Cats is administered, adult fleas on the cat will be killed. However, re-infestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Cats treated with Advocate Hund, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the cat.
Ear Mite Treatment: For the treatment of ear mites (Otodectes cynotis), Advantage Multi for Cats should be administered once as a single topical dose. Monthly use of Advantage Multi for Cats will control any subsequent ear mite infestations.
Intestinal Nematode Treatment: For the treatment and control of intestinal hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara cati (adults and fourth stage larvae), Advantage Multi for Cats should be administered once as a single topical dose.
Depiction of opening of Advantage Multi for Cats tube Depiction of application of Advantage Multi for Cats on cat's skin
ANIMAL SAFETY:
Dose Tolerance Study: Eight healthy juvenile cats were topically dosed with a single application of Advantage Multi for Cats at 10 times the recommended dose volume. Mild, transient hypersalivation occurred in two of the cats.
Oral Study in Cats: The oral safety of Advantage Multi for Cats was tested in case of accidental oral ingestion. The maximum topical dose was orally administered to twelve healthy 9-week-old kittens. Hypersalivation (8 of 12 kittens) and vomiting (12 of 12 kittens) were observed immediately post-treatment. Tremors developed in one kitten within 1 hour, resolving without treatment within the next hour. All 12 kittens were either anorexic or had decreased appetite for at least 1 day following treatment. In 3 kittens, the anorexia or decreased appetite continued into the second week following treatment. There was a post-treatment loss of body weight in treated kittens compared to control kittens. In a pilot safety study using kittens younger in age and lighter in weight than allowed by product labeling, an 8-week old kitten weighing 0.6 kg orally received 2X of the label topical dose (0.46 mL/kg). Immediately after dosing, it vomited, had labored breathing and slight tremors. Within 4 hours, it was normal, but was found dead on day 6. Necropsy could not determine the cause of death.
Study in Heartworm Positive Cats: Young adult cats were inoculated subcutaneously with third-stage D. immitis larvae. At 243-245 days post-infection, immunoserology and echocardiography were performed to identify cats with adult heartworm burdens similar to naturally-acquired infections. Two groups were treated topically with either Advantage Multi for Cats at the label dose or placebo, once every 28 days, for three consecutive treatments. A third group was treated topically, once, with Advantage Multi for Cats at 5X the label dose. Sporadic vomiting and labored breathing related to heartworm burden were observed in the treatment and control groups. There was no difference between treatment groups in the numbers of adult D. immitis recovered at study conclusion. No adverse reactions were associated with the topical application of Advantage Multi for Cats to experimentally heartworm-infected cats.
INDICATIONS:
Advantage Multi for Cats is indicated for the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.
PRECAUTIONS:
The safety of Advantage Multi for Cats has not been established in breeding, pregnant, and lactating ferrets.
Treatment of ferrets weighing less than 2.0 lbs (0.9 kg) should be based on a risk-benefit assessment.
The effectiveness of Advantage Multi for Cats in ferrets weighing over 4.4 lbs (2.0 kg) has not been established.
ADVERSE REACTIONS:
Adverse reactions in ferrets following treatment included: pruritus/scratching, scabbing, redness, wounds and inflammation at the treatment site; lethargy; and chemical odor. These adverse reactions resolved without additional therapy. Owners also reported stiffening of the hair at the treatment site, however, this is expected with application of a topical product and is not considered an adverse reaction.
Three human adverse reactions were reported. An owner’s finger became red following skin contact with the product. One owner reported a headache caused by the chemical odor of the product. One owner reported a tingling sensation of the lips after kissing the treatment site.
ANIMAL SAFETY:
DOSAGE AND ADMINISTRATION:
The recommended minimum dose for a ferret is 9 mg/lb (20 mg/kg) Advocate Hund and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.
Advantage Multi 9
Only the 0.4 mL applicator tube volume (Advantage Multi 9) should be used on ferrets.
Do not apply to irritated skin.
1. Remove one dose applicator tube from the package. Administer the entire contents of the Advantage Multi for Cats tube (0.4 mL).
2. While holding the tube in an upright position, remove the cap from the tube.
3. Turn the cap over and push the other end of cap onto the tip of the tube.
4. Twist the cap to break the seal and then remove cap form the tube.
5. Part the hair on the back of the ferret’s neck at the case of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift tube away from skin before releasing pressure on tube.
Do not get this product in the ferret’s mouth or eyes or allow the ferret to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some ferrets. This is temporary and does not affect the safety or effectiveness of the product.
Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Cats should be administered at one-month intervals. Advantage Multi for Cats may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Cats immediately and resume the monthly dosing schedule.
Flea Treatment: For the treatment of flea infestations on ferrets, Advantage Multi for Cats should be administered at one-month intervals. If the ferret is already infested with fleas when the first dose of Advantage Multi for Cats is administered, adult fleas on the ferret will be killed. However, re-infestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated.
Depiction of opening of Advantage Multi for Cats tube Depiction of application of Advantage Multi for Cats on ferret's skin
STORAGE INFORMATION:
HOW SUPPLIED:
3 x 0.23 mL tubes
6 x 0.4 mL tubes
6 x 0.8 mL tubes
Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328 and 6,001,858.
NADA # 141-254, Approved by FDA
© 2015 Bayer HealthCare LLC
Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer.
Made in Germany.
Bayer HealthCare LLC
Animal Health Division
Kansas 66201 U.S.A.
Select the most affordable brand or generic drug
Advocate Hund - Frequently asked Questions
Can Advocate Hund be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
Can Advocate Hund be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Advocate Hund be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
Patient reports
Patient reported useful
Patient reported side effects
Patient reported price estimates
Patient reported frequency of use
Patient reported doses
Patient reported time for results
Patient reported administration
Patient reported age
Patient reviews
There are no reviews yet. Be the first to write one!
Information checked by Dr. Shikha Narang, MD Pharmacology
You should consult a doctor about the dosage before using this medicine!
Advocate
This is a summary of the European Public Assessment Report (EPAR). It explains how the Agency assessed this veterinary medicine to recommend its authorisation in the European Union (EU) and its conditions of use. It is not intended to provide practical advice on how to use Advocate.
For practical information about using Advocate, animal owners or keepers should read the package leaflet or contact their veterinarian or pharmacist.
Advocate is a medicine used on cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections (caused by several different types of parasites):
- for the treatment and prevention of flea infestations in cats, ferrets and dogs
- as part of treatment strategies for flea allergy dermatitis (an allergic reaction to flea bites) in cats and dogs
- for the treatment of ear mite infestations in cats and dogs
- for the treatment of notoedric mange in cats
- for the treatment of biting lice infestations in dogs
- for the treatment of skin diseases in dogs caused by parasitic mites (sarcoptic mange and demodicosis)
- for the prevention of heartworm disease in cats, ferrets and dogs
- for the prevention and treatment of dirofilariosis (infection with the heartworms Dirofilaria immitis and Dirofilaria repens) in dogs.
- for the prevention and treatment of lungworm in dogs
- for the prevention of spirocercosis (a worm infection affecting the gullet) in dogs
- for the treatment of infections with certain (as specified in the package leaflet) gastrointestinal roundworms in cats and dogs.
It contains two active substances, imidacloprid and moxidectin.
Advocate is available as a spot-on solution and comes in different strengths and pack sizes, depending on whether it is for use on cats, on ferrets, or on dogs, and on the size of the animal being treated. The medicine can only be obtained with a prescription. Advocate is applied to cats, ferrets and dogs from pre-filled pipettes. These are small plastic droppers, available in different sizes depending on the size of the animal, which are filled with the correct amount of Advocate for one treatment. The content of a full pipette is applied onto the animal’s skin, after parting the fur. In cats and ferrets, the product is applied to the animal’s neck at the base of the skull. In dogs it is applied between the shoulder blades at the bottom of the dog’s head, but for large dogs (above 25 kg) the product should be applied in 3 or 4 spots along the dog’s back, whilst it is standing, from between its shoulder blades to the base of its tail.
The dose and frequency of application depends on why Advocate is being used and whether it is used in cats, ferrets or dogs; the package leaflet includes detailed information on dosage and duration of treatment.
Imidacloprid interferes with certain specific receptors (nicotinergic acetylcholine receptors) in the nervous systems of lice and fleas, which results in their subsequent paralysis and death.
Moxidectin causes paralysis and death of nematodes and heartworms by interfering with the way signals are passed between nerve cells (neurotransmission) in the parasites’ nervous system.
The effectiveness of the products against the specified parasites was investigated in laboratory studies. Subsequently the efficacy was confirmed in several field studies in cats and dogs, which were conducted in several different European geographical locations. Cats and dogs from various breeds, age groups and weights were treated. Field studies involving heartworm in dogs were conducted both in the USA and Europe. The effectiveness of the product was measured by looking at the number of live parasites at various times after treatment. Efficacy studies were also performed in ferrets.
The results of the laboratory and field trials in cats, ferrets and dogs showed that Advocate is effective, when used as detailed in the package leaflet (see “What is Advocate used for?” above, or for more details see the package leaflet).
a, it might salivate for a short period and might show signs such as a lack of muscular co-ordination, shaking, abnormal breathing and/or vomiting.
Although no side effects have been confirmed in ferrets, similar side effects could occur rarely.
Dogs and cats weighing less than 1 kg and ferrets weighing less than 0.8 kg should only be treated after special consideration by the veterinarian.
Advocate should not be used in kittens under 9 weeks of age or in puppies under 7 weeks of age.
Advocate should not be used in dogs classified as Class 4 for heartworm disease.
Advocate comes in different strengths and different pipette sizes depending on whether it is for use on cats, ferrets or dogs. It is very important that the cat products should only be used for cats, and the dog products for dogs. Only the product called “Advocate spot-on solution for small cats and ferrets” should be used for ferrets. Advocate should not be used for any other animal species.
For the full list of restrictions, see the package leaflet.
Skin contact with the pipette contents should be avoided and animals should not be stroked or groomed until the application site is dry. When administering Advocate, the user should not smoke, eat or drink, and should wash their hands thoroughly after use. If accidental exposure occurs, the eyes should be rinsed with water or the skin washed with soap and water.
People with a known sensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution.
The solvent in Advocate may stain or damage certain materials including leather, fabrics, plastics and finished surfaces, so contact between the product and such surfaces should be avoided.
The Agency’s Committee for Medicinal Products for Veterinary Use (CVMP) concluded that Advocate’s benefits are greater than its risks and recommended that Advocate be approved for use in the EU.
The European Commission granted a marketing authorisation valid throughout the EU for Advocate on 2 April 2003.
For more information about treatment with Advocate, animal owners of keepers should read the package leaflet or contact their veterinarian or pharmacist.
This EPAR was last updated on 15/06/2017 .
Authorisation details
Product details
Publication details
Bayer Animal Health GmbH
Contact address:
Bayer Animal Health GmbH
Product information
Product information
18/05/2017 Advocate -EMEA/V/C/000076 -IAIN/0038
- Annex I - Summary of product characteristics
- Annex IIA - Manufacturing-authorisation holder responsible for batch release
- Annex IIB - Conditions of the marketing authorisation
- Annex IIIA - Labelling
- Annex IIIB - Package leaflet
Please note that the size of the above document can exceed 50 pages.
You are therefore advised to be selective about which sections or pages you wish to print.
Pharmacotherapeutic group
Therapeutic indication
For dogs suffering from, or at risk from, mixed parasitic infections:
- For the treatment and prevention of flea infestation (Ctenocephalides felis),
- the treatment of biting lice (Trichodectes canis),
- the treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis),
- the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis),
- the treatment of circulating microfilariae (Dirofilaria immitis),
- the treatment of cutaneous dirofilariosis (adult stages of Dirofilaria repens)
- the prevention of cutaneous dirofilariosis (L3 larvae of Dirofilaria repens),
- the reduction of circulating microfilariae (Dirofilaria repens),
- the prevention of angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum),
- the treatment of Angiostrongylus vasorum and Crenosoma vulpis,
- the prevention of spirocercosis (Spirocerca lupi),
- the treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis).
The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
For cats suffering from, or at risk from, mixed parasitic infections:
- For the treatment and prevention of flea infestation (Ctenocephalides felis),
- the treatment of ear mite infestation (Otodectes cynotis),
- the treatment of notoedric mange (Notoedres cati),
- the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis),
- the treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara cati and Ancylostoma tubaeforme).
The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
For ferrets suffering from, or at risk from, mixed parasitic infections:
- For the treatment and prevention of flea infestation (Ctenocephalides felis),
- the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis).
Assessment History
Changes since initial authorisation of medicine
Initial marketing-authorisation documents
Authorised
This medicine is approved for use in the European Union
Advocate Spot On for Dogs 250 (10-25kg)
This item requires a vet's prescription
.jpg)
Select from the following options:
- Save 52%
- Vet price £30.17
- Our price £14.60
Estimated dispatch within 24 hours (subject to stock) See our delivery options
Advocate Spot On for Large Dogs is a treatment for fleas and their larvae, roundworm, hookworm, heartworm and ear mites in dogs.
It also treats lungworm, whipworm, biting lice, sarcoptes and demodex.
Advocate Spot On is supplied in packs of 3 or 6 single use pipettes.
Advocate for dogs is a prescription item and will be sent once a valid prescription is received.
Full instructions for using Advocate for Dogs is included.
Looking for a different size?
Save over 50% on Advocate for Dogs and Cats by shopping with us:
Advocate for Dogs contains two active substances, imidacloprid and moxidectin.
Advocate for dogs comes in different strengths and pack sizes, depending on the size of the animal being treated. The medicine can only be obtained with a prescription. Advocate is applied from pre-filled pipettes. These are small plastic droppers, available in different sizes depending on the size of the animal, which are filled with the correct amount of Advocate for one treatment. The content of a full pipette is applied onto the animal’s skin, after parting the fur. Advocate for dogs is applied between the shoulder blades at the bottom of the dog’s head, but for large dogs (above 25 kg) the product should be applied in 3 or 4 spots along the dog’s back, whilst it is standing, from between its shoulder blades to the base of its tail.
The dose and frequency of application depends on why Advocate is being used; the package leaflet includes detailed information on dosage and duration of treatment.
Advocate for Dogs is available to buy from Pet Drugs Online at up to 52% cheaper than your vet.
How does Advocate for Dogs work?
Imidacloprid interferes with certain specific receptors (nicotinergic acetylcholine receptors) in the nervous systems of lice and fleas, which results in their subsequent paralysis and death.
Moxidectin causes paralysis and death of nematodes and heartworms by interfering with the way signals are passed between nerve cells (neurotransmission) in the parasites’ nervous system.
To check the most up to date information about this product, please read its Summary of Product Characteristics (SPC) on the Veterinary Medical Directorate’s (VMD) Product Information Database:
For orders over £29 postage is free. For orders under £29 we charge £2.99 for postage
For Light items (under 2kg) our standard method is Royal Mail Second Class (there are a few exceptions, so if in doubt check our Delivery page).
For more information, view our Delivery page.
Product reviews for prescription products are not allowed by the RCVS. But here is what our customers say about our service:
Service reviews have been compiled from 36970 customer reviews
Hurtig levering, let at navigere og finde produkter
Fantastic product, our dog has taken to " gastro intestnal low fat " very well and she likes it. Delivery was very fast and the price was better that the vet's
Quickly received, thank you
Prices are well below the vets prices and with trouble free ordering and delivery!
Easy to order, quick delivery. But would be better if you could register more than 1 pet. Great service many thanks Gary
great - no problems at all
As usual, great service. Good price and would recommend
Fast reliable service, easy to use and far cheaper than buying from vets
Easy to use site and a lot cheaper than the vets!
The service is great it’s easy to order on line I think this is the third time I’ve used this online service will be using it again and again great value for money cheaper than the vets 👍
© 2018 Pet Drugs Online
A Registered RCVS Vet Practice (7159324) &
An Accredited Veterinary Medicines Internet Retailer (2033874)
Gærum Dyreklinik
² Navigation
Advocate til hund og kat
<h2><span style=”color: #ff6600;”>Kan man anvende advocate beregnet til en hund til sin kat ?</span></h2>
jeg har noget Advocate parasit middel til hund liggende..
mit spørgsmål er, om jeg kan bruge dette til kat, hvis jeg doserer
Er indholdstofferne de samme for hund og kat ?
Nej det må du endelig ikke. Advocate til hund indeholder 2,5 % Moxidectin i modsætning til advocate til kat, der kun indeholder 1 % Moxidectin.
Helt generelt bør man ikke anvende medicin beregnet til andre dyrearter til katte. Dette skyldes, at katte har et meget anderledes enzymsystem i leveren og derfor i mange tilfælde ikke kan nedbryde medicinen på samme måde som andre dyrearter, hvorfor forgiftningsrisikoen er stor hos katte.
Med Venlig Hilsen
Åbningstider
Mandag, onsdag og fredag: Kl.8:30 - Kl.17:00
Tidsbestilling på tlf. 2834 6082.
eller book en tid online:
Kredit på dyrlægeregningen? Intet problem.
Er der noget du ikke kan finde, så prøv at søge her
Tilmeld dig vores nyhedsbreve her
Det er muligt, at betale med de fleste kreditkort typer og E-dankort i Gærum Dyrekliniks netbutik. Du kan også betale med mobilpay og bankoverførsel.
Leveringsbestemmelser og returpolitik
Køb nu betal senere.
Køb i vores netbutik i dag og betal først når du vil eller afdrag dit køb over 3, 6, 12 eller 24 måneder.
Der kan efter ansøgning også gives kredit på op til 20.000 kr. Denne kredit er dog ikke gebyr og rentefri. Ansøgning om kredit på over 2.000 kr behandles straks.
Fragtpriser og sådan undgår du fragt.
1. Køb for over 425,00 kr.: Så betaler vi fragten til en GLS shop.
Ved meget tunge produkter skal du dog købe for over 3000 kr før vi betaler fragten. Men så leveres købet til gengæld på din adresse.
2. Afhent selv i klinikken: Du kan altid afhente alle produkter fragtfrit i klinikken.
Moxidectin
In some countries, this medicine may only be approved for veterinary use.
CAS registry number (Chemical Abstracts Service)
Chemical Formula
Molecular Weight
Therapeutic Category
Chemical Names
(6R,25S)-5-O-Demetyl-28-deoxy-25-[(E)-1,3-dimetyl-1-butenyl]-6,28-epoxy-23-oxomilbemycin B 23-(E)-(O-metyloxime) (WHO)
Milbemycin B, 5-O-demetyl-28-deoxy-25-(1,3-dimetyl-1-butenyl)-6,28-epoxy-23-(metoxyimino)-, [6R,23E,25S(E)]- (USAN)
Foreign Names
- Moxidectinum (Latin)
- Moxidectin (German)
- Moxidectine (French)
- Moxidectina (Spanish)
Generic Names
- Moxidectin (OS: USAN, BAN)
- CL 301423 (IS)
- Moxidectin (PH: BP vet. 2015, USP 38)
- Moxidectin for veterinary use (PH: Ph. Eur. 8)
- Moxidectinum ad usum veterinarium (PH: Ph. Eur. 8)
Brand Names
- Advantage Multi (Moxidectin and Imidacloprid (veterinary use))
Bayer Animal Health, United States
Animal Health Division Bayer HealthCare AG, Austria; Bayer, Italy; Bayer Animal, Netherlands; Bayer Animal Health, Belgium; Bayer Animal Health, United Kingdom; Bayer Animal Health, Norway; Bayer Australia Ltd Animal Health, Australia; Bayer Santé Animale, France; Lidorr Chemicals, Israel; Orion Pharma Eläinlääkkeet, Finland
Bayer New Zealand, New Zealand
Bayer New Zealand, New Zealand
Provet, Switzerland
Provet, Switzerland
Bayer Vital, Germany
Bayer Vital, Germany
Zoetis Australia, Australia
Bayer HealthCare LLC, United States
Fort Dodge Animal Health, South Africa; Virbac, Australia
Fort Dodge Animal Health, South Africa; Virbac, Australia
Pfizer Animal Health, United Kingdom; Virbac, Australia
Bayer AH, South Africa; Boehringer Ingelheim Vetmedica, United States; Firma Netjes, Netherlands; Holland Animal Care, Netherlands; Orion Pharma Animal Health, Sweden; Pfizer, Austria; Pfizer Animal Health, United Kingdom; Pfizer Animal Health, Netherlands; Virbac, Australia; Wirtz, Netherlands; Zoetis, Finland; Zoetis, Ireland; Zoetis, New Zealand
Zoetis, Switzerland; Zoetis, Germany; Zoetis, Italy; Zoetis Belgium, Belgium
Boehringer Ingelheim Vetmedica, United States; Zoetis, Switzerland; Zoetis, Germany; Zoetis, Italy; Zoetis Belgium, Belgium
Zoetis, Germany; Zoetis, Italy; Zoetis Belgium, Belgium
Zoetis, Switzerland; Zoetis Belgium, Belgium
Zoetis, Switzerland
Orion Pharma Animal Health, Sweden
Zoetis, New Zealand
Zoetis, New Zealand
Zoetis, New Zealand
Zoetis, New Zealand
Zoetis, Switzerland; Zoetis, Ireland; Zoetis Belgium, Belgium
Pfizer, Austria; Pfizer Animal Health, Netherlands; Zoetis, Germany
Zoetis, France
Zoetis, France; Zoetis, Italy
Zoetis Australia, Australia
Pfizer, Poland; Pfizer Animal Health, United Kingdom; Pfizer Animal Health, South Africa; Zoetis, Finland; Zoetis Australia, Australia
Equi Products, Netherlands; Fort Dodge Laboratories, Israel; Novivet, Netherlands; Pfizer, Austria; Pfizer Animal Health, United Kingdom; Pfizer Animal Health, Netherlands; Zoetis, Switzerland; Zoetis, Germany; Zoetis, Finland; Zoetis, France; Zoetis, Ireland; Zoetis, Italy; Zoetis Belgium, Belgium
Zoetis, New Zealand
Fort Dodge, Israel; Pfizer, Austria; Pfizer Animal Health, Netherlands; Zoetis, Switzerland; Zoetis, Germany; Zoetis, France; Zoetis, Ireland; Zoetis, Italy; Zoetis Belgium, Belgium; Zoetis Finland Oy, Norway
Continental Farmaceutica, Ireland
Continental Farmaceutica, Ireland
Merial, New Zealand
Merial, New Zealand
Merial, New Zealand
Lilly Vet, France; Lilly-Elanco, Italy
Lilly-Elanco, Italy
Ancare Australia, Australia
Ancare Australia, Australia
Ancare Australia, Australia
Bayer New Zealand, New Zealand
Bayer New Zealand, New Zealand
Zoetis, Ireland
AgVantage Animal Health Products, Australia
AgVantage Animal Health Products, Australia
Pfizer Animal Health, United Kingdom
Bayer Australia Ltd Animal Health, Australia
Bayer Australia Ltd Animal Health, Australia
Pfizer Animal Health, United Kingdom
Zoetis, United States; Zoetis Australia, Australia
Zoetis, United States
Zoetis, United States
Zoetis, United States
Zoetis Australia, Australia
AgVantage Animal Health Products, Australia
AgVantage Animal Health Products, Australia
Bayer New Zealand, New Zealand
Zoetis, New Zealand
Zoetis, New Zealand
Zoetis, United Kingdom
Zoetis, United Kingdom
Zoetis, United Kingdom
Click for further information on drug naming conventions and International Nonproprietary Names.
Important Notice: The Drugs.com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
Drugs.com Mobile Apps
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.
About
Terms & Privacy
Subscribe to receive email notifications whenever new articles are published.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Jan 31st, 2018), Cerner Multum™ (updated Feb 2nd, 2018), Wolters Kluwer™ (updated Feb 2nd, 2018) and others. To view content sources and attributions, please refer to our editorial policy.
We comply with the HONcode standard for trustworthy health information - verify here
Advocate Spot-on Solution for Dogs & Cats
Selection of 11 products from
Estimated dispatch within 1 working day.
Estimated dispatch within 1 to 3 working days.
Estimated dispatch within 1 working day.
Estimated dispatch within 1 working day.
Estimated dispatch within 1 to 3 working days.
Estimated dispatch within 1 working day.
Estimated dispatch within 1 working day.
Estimated dispatch within 1 working day.
Estimated dispatch within 1 to 3 working days.
Estimated dispatch within 1 to 3 working days.
Estimated dispatch within 1 to 3 working days.
Description
Advocate is a spot-on treatment used to control internal and external parasites affecting dogs, cats and ferrets. The contents of one pipette are applied to the skin on the back of the neck between the parted hair. The area is then left to dry, which might take a few hours. One of the active ingredients, moxidectin, is absorbed through the skin and travels around the body, treating internal parasites such as worms. The other active ingredient, imidacloprid, transfers across the surface of the body, dissolved in the oils on the surface of the skin and hairs. Surface living parasites such as fleas are killed on contact.
Of all the products available, Advocate probably kills the broadest range of parasites affecting dogs, cats and ferrets
Presentation
Advocate spot-on solution for cats and ferrets is a clear yellow to brownish solution containing 100 mg/ml imidacloprid and 10 mg/ml moxidectin with benzyl alcohol and Butylhydroxytoluene 1 mg/ml (E 321 as an antioxidant). Each pipette of the small cat and ferret presentations contains 0.4 ml (40 mg imidacloprid, 4 mg moxidectin), the large cat presentation contains 0.8 ml (80 mg imidacloprid, 8 mg moxidectin).
Advocate spot-on solution for dogs is a clear yellow to brownish solution containing 100 mg/ml imidacloprid and 25 mg/ml moxidectin with benzyl alcohol and Butylhydroxytoluene 1 mg/ml (E321 as an antioxidant). Each pipette of the dog presentations contains either 0.4 ml (40 mg imidacloprid, 10 mg moxidectin), 1.0 ml (100 mg imidacloprid, 25 mg moxidectin), 2.5 ml (250 mg imidacloprid, 62.5 mg moxidectin) or 4.0 ml (400 mg imidacloprid, 100 mg moxidectin).
For use in cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections:
For cats: For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of ear mite infestation (Otodectes cynotis), prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis) and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara cati and Ancylostoma tubaeforme). The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
For ferrets: For the treatment and prevention of flea infestation (Ctenocephalides felis) and the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis).
For dogs: For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of biting lice (Trichodectes canis), treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis), prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis) and angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum), treatment of Angiostrongylus vasorum and Crenosoma vulpis and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis). The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
Dosage and administration
Dosage schedule
The recommended minimum doses for cats are 10 mg/kg body weight imidacloprid and 1.0 mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Advocate for cats. Dosage schedule for ferrets: one pipette of Advocate spot-on solution for small cats and ferrets (0.4 ml) should be administered per animal. Do not exceed the recommended dose. The recommended minimum doses for dogs are 10 mg/kg body weight imidacloprid and 2.5 mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Advocate for dogs.
The treatment schedule for all species should be based on the local epidemiological situation.
Cats (Refer to Table 1)
Weight of CAT [kg]
Pipette size to be used
Imidacloprid [mg/kg bw]
Moxidectin [mg/kg bw]
Advocate for small cats and ferrets
Advocate for large cats
the appropriate combination of pipettes
Dogs(Refer to Table 2)
Weight of DOG [kg]
Pipette size to be used
Imidacloprid [mg/kg bw]
Moxidectin [mg/kg bw]
Advocate for small dogs
Advocate for medium dogs
Advocate for large dogs
Advocate for extra-large dogs
the appropriate combination of pipettes
Flea treatment and prevention (Cats and Dogs)
One treatment prevents future flea infestation for 4 weeks. Existing pupae in the environment may emerge for 6 weeks or longer after treatment is initiated, depending upon climatic conditions. Therefore, it may be necessary to combine Advocate treatment with environmental treatments aimed at breaking the flea life cycle in the surroundings. This can result in a more rapid reduction in the household flea population. The product should be administered at monthly intervals when used as part of a treatment strategy for flea allergy dermatitis.
Flea treatment and prevention (Ferrets)
One treatment prevents future flea infestation for 3 weeks. Under heavy flea pressure it may be necessary to repeat the dose after 2 weeks.
Treatment of ear mite infestation (Otodectes cynotis) (Cats & Dogs)
A single dose of the product should be administered. In dogs, loose debris should be gently removed from the external ear canal at each treatment. For both cats and dogs, a further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment. Do not apply directly to the ear canal.
Treatment of biting lice (Trichodectes canis) (Dogs)
A single dose should be administered. A further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.
Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis) (Dogs)
A single dose should be administered twice 4 weeks apart.
Treatment of demodicosis (caused by Demodex canis) (Dogs)
The administration of a single dose every 4 weeks for 2 to 4 months is efficacious against Demodex canis and leads to a marked improvement of clinical signs particularly in mild to moderate cases. Especially severe cases may require more prolonged and more frequent treatment. To achieve the best possible response in these severe cases, at the discretion of the veterinarian, Advocate can be applied once a week and for a prolonged time. In all cases it is essential that the treatment should be continued until skin scrapings are negative on at least 2 consecutive monthly occasions. Treatment should be stopped in dogs that show no improvement or do not respond in mite count after 2 months treatment. Alternative treatment should be administered. Seek the advice of your veterinarian.
As demodicosis is a multi-factorial disease, where possible, it is advisable to also treat any underlying disease appropriately.
Heartworm prevention (Cats, Ferrets & Dogs)
Cats, ferrets and dogs in areas endemic for heartworm, or those which have travelled to endemic areas, may be infected with adult heartworms. Therefore prior to treatment with Advocate, the advice provided in Contra-Indications and Warnings etc should be considered. For prevention of heartworm disease, the product must be applied at regular monthly intervals during the time of the year when mosquitoes (the intermediate hosts which carry and transmit heartworm larvae) are present. The product may be administered throughout the year or at least 1 month before the first expected exposure to mosquitoes. Treatment should continue at regular monthly intervals until 1 month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended that the same day or date be used each month. When replacing another heartworm preventative product in a heartworm prevention programme, the first treatment with Advocate must be given within 1 month of the last dose of the former medication. In non-endemic areas there should be no risk of animals having heartworm. Therefore they can be treated without special precautions.
Roundworm and hookworm treatment (Cats)
In areas endemic for heartworm, monthly treatment may significantly reduce the risk of re-infection caused by the respective roundworms and hookworms. In areas non-endemic for heartworm, the product can be used as part of a seasonal prevention programme against fleas and gastrointestinal nematodes.
Roundworm, hookworm and whipworm treatment (Dogs)
In areas endemic for heartworm, monthly treatment may significantly reduce the risk of re-infection caused by the respective round-, hook- and whipworms. In areas non-endemic for heartworm, the product can be used as part of a seasonal prevention programme against fleas and gastrointestinal nematodes. Studies have shown that monthly treatment of dogs will prevent infections caused by Uncinaria stenocephala.
Treatment and Prevention of Angiostrongylus vasorum (Dogs)
A single dose should be administered. A further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.
In endemic areas regular four weekly application will prevent angiostrongylosis and patent infection with Angiostrongylus vasorum.
Treatment of Crenosoma vulpis (Dogs)
A single dose should be administered
Method of administration
For external use only.
Remove one pipette from the package. Then hold the pipette in an upright position, and twist and pull off the cap. Reverse the cap and use it to twist and remove the seal from the pipette, as shown. See Figure 1.
Figure 1: Opening a pipette
Cats and Ferrets
Part the fur on the animal's neck at the base of the skull until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette firmly several times to empty its contents directly onto the skin. Application at the base of the skull will minimise the opportunity for the animal to lick the product. Apply only to undamaged skin. See figure 2.
Figure 2: Administration to the Cat or Ferret
For dogs up to 25kg
With the dog in a standing position, part the coat between the shoulder blades until the skin is visible. Wherever possible apply to undamaged skin. Place the tip of the pipette on the skin and squeeze the pipette firmly several times to empty its contents directly onto the skin. See Figure 3.
Figure 3: Administration to dogs up to 25kg
For dogs of more than 25 kg
For easy application the dog should be standing. The entire contents of the pipette should be applied evenly as 3 or 4 spots along the top of the back, from between the shoulders to the base of the tail. At each spot, part the coat until the skin is visible. Wherever possible apply to undamaged skin. Place the tip of the pipette on the skin and gently squeeze the pipette to expel a portion of its contents directly onto the skin. Do not apply an excessive amount of solution at any one spot, as that could cause some of the product to run down the animal’s side. See Figure 4.
Figure 4: Administration to dogs over 25kg
Use During Pregnancy and Lactation
The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Laboratory studies with either imidacloprid or moxidectin in rats and rabbits have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. Use only according to the risk-benefit assessment by the responsible veterinarian.
Contra-indications, warnings, etc
Do not use in kittens under 9 weeks of age.
Do not use in puppies under 7 weeks of age.
Treatment of cats or dogs weighing less than 1 kg, and ferrets weighing less than 0.8 kg should be based on a risk-benefit assessment.
Do not use in the case of hypersensitivity to the active substances or to any of the excipients.
There is limited experience on the use of the product in sick and debilitated animals, thus the product should only be used based on a risk-benefit assessment for these animals.
For cats, the corresponding "Advocate spot-on solution for cat" product, which contains 100 mg/ml imidacloprid and 10 mg/ml moxidectin, must be used.
For ferrets: Do not use Advocate for large cats (0.8ml) or Advocate for dogs (any size), only "Advocate for small cats and ferrets" (0.4 ml) must be used. The product’s efficacy has not been tested in ferrets weighing over 2 kg and therefore the duration of effect might be shorter in these animals.
For dogs, the corresponding "Advocate for dog" product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used.
The product tastes bitter. Salivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimize licking of the application site.
In case of accidental oral uptake, symptomatic treatment should be administered. There is no known specific antidote. The use of activated charcoal may be beneficial. After accidental oral ingestion (i.e. licking at the site of application) or overdose, neurological signs (most of which are transient) such as ataxia, generalised tremors, ocular signs (dilated pupils, little pupillary reflex, nystagmus), abnormal respiration, salivation and vomiting may be observed in very rare cases.
The use of the product may result in transient pruritus in the animal. On rare occasions greasy fur, erythema and vomiting can occur. These signs disappear without further treatment. The product may, in rare cases cause local hypersensitivity reactions. The product may in very rare cases cause at the application site a sensation resulting in transient behavioural changes such as lethargy, agitation, and inappetence.
Care should be taken that the content of the pipette or the applied dose does not come into contact with the eyes or mouth of the recipient and/or other animals.
Do not allow recently treated animals to groom each other.
When the product is applied in 3 to 4 separate spots in larger dogs, specific care should be taken to prevent the animal licking the application sites. Oral uptake by Collies, Old English Sheepdogs and related breeds or crossbreeds should be prevented.
During treatment with Advocate no other antiparasitic macrocyclic lactone should be administered. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described above. In particular, oral uptake by the recipient and/or other animals in close contact should be prevented.
Ivermectin-sensitive Collie dogs tolerated up to 5 times the recommended dose repeated at monthly intervals without any adverse effects, but the safety of application at weekly intervals has not been investigated in ivermectin-sensitive Collie dogs. When 40% of the unit dose was given orally, severe neurological signs were observed. Oral administration of 10% of the recommended dose produced no adverse effects.
Up to 10 times the recommended dose was tolerated in adult dogs with no evidence of adverse effects or undesirable clinical signs. Five times the recommended minimum dose applied at weekly intervals for 17 weeks was investigated in dogs aged over 6 months and tolerated with no evidence of adverse effects or undesirable clinical signs.
Up to 10 times the recommended dose was tolerated in cats with no evidence of adverse effects or undesirable clinical signs.
The product was administered to kittens and puppies at up to 5 times the recommended dose, every 2 weeks for 6 treatments, and there were no serious safety concerns. Transient mydriasis, salivation, vomiting and transient rapid respiration were observed.
The product was administered to ferrets at 5 times the recommended dose, every 2 weeks for 4 treatments, and there was no evidence of adverse effects or undesirable clinical signs.
It is recommended that cats and ferrets living in, or travelling to areas endemic for heartworm are treated monthly with the product to protect them from heartworm disease. Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended that attempts be made to check the heartworm status of any cat and ferret aged over 6 months, before beginning prophylactic treatment, as use of the product on cats or ferrets which have adult heartworms may cause serious adverse effects, including death. If adult heartworm infection is diagnosed, the infection should be treated in accordance with current scientific knowledge.
Although the product may be safely administered to dogs infected with adult heartworms, it has no therapeutic effect against adult Dirofilaria immitis. It is therefore recommended that all dogs 6 months of age or more, living in areas endemic for heartworm, should be tested for existing adult heartworm infection before being treated with the product.
Dogs infected with adult heartworms tolerated up to 5 times the recommended dose, every 2 weeks for 3 treatments, without any adverse effects.
No interactions between Advocate and routinely used veterinary medicinal products or medical or surgical procedures have been observed.
Brief contact of the animal with water on one or two occasions between monthly treatments is unlikely to significantly reduce the efficacy of the product. However, frequent shampooing or immersion of the animal in water after treatment may reduce the efficacy of the product.
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
The solvent in Advocate may stain or damage certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.
User Safety
Avoid contact with skin, eyes or mouth.
Do not eat, drink or smoke during application.
Wash hands thoroughly after use.
In case of accidental spillage onto skin, wash off immediately with soap and water.
After application do not stroke or groom animals until the application site is dry.
People with a known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. In very rare cases the product may cause skin sensitisation or transient skin reactions (for example numbness, irritation or burning/tingling sensation). In very rare cases the product may cause respiratory irritation in sensitive individuals.
If the product accidentally gets into eyes, they should be thoroughly flushed with water.
If skin or eye symptoms persist, or the product is accidentally swallowed, seek medical attention and show the package insert to the physician.
Environmental Safety
Advocate should not be allowed to enter surface waters as it has harmful effects on aquatic organisms: moxidectin is highly toxic to aquatic organisms. Dogs should not be allowed to swim in surface waters for 4 days after treatment.
Any unused product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Pharmaceutical precautions
Do not store above 30°C.
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years
Legal category
Packaging Quantities
White polypropylene unit dose pipette with screw cap.
Advocate Spot-on solution for Small Cats and Ferrets
Blister pack containing 3 or 6 unit dose pipettes: 0.4 ml per pipette
Advocate Spot-on solution for Large Cats
Blister pack containing 3 or 6 unit dose pipettes: 0.8 ml per pipette
Advocate Spot-on solution for Small Dogs
Blister pack containing 3 unit dose pipettes: 0.4 ml per pipette
Advocate Spot-on solution for Medium Dogs
Blister pack containing 3 or 6 unit dose pipettes: 1.0 ml per pipette
Advocate Spot-on solution for Large Dogs
Blister pack containing 3 or 6 unit dose pipettes: 2.5 ml per pipette
Advocate Spot-on solution for Extra-Large Dogs
Blister pack containing 3 or 6 unit dose pipettes: 4.0ml per pipette
Further information
Pharmacotherapeutic group: therapeutic antiparasitic agent; ATCvet code: QP54AB52.
Imidacloprid, 1-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it is more accurately described as a chloronicotinyl nitroguanidine. Imidacloprid is effective against larval flea stages and adult fleas. Flea larvae in the pet’s surroundings are killed after contact with a pet treated with the product. Imidacloprid has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS) of the flea. The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Due to the weak nature of the interaction with mammalian nicotinergic receptors and the postulated poor penetration through the blood-brain barrier in mammals, it has virtually no effect on the mammalian CNS. Imidacloprid has minimal pharmacological activity in mammals.
Moxidectin, 23-(O-methyloxime)-F28249 alpha is a second-generation macrocyclic lactone of the milbemycin family. It is a parasiticide which is active against many internal and external parasites. Moxidectin is active against larval stages (L3, L4) of Dirofilaria immitis. It is also active against gastrointestinal nematodes. Moxidectin interacts with GABA and glutamate-gated chloride channels. This leads to opening of the chloride channels on the postsynaptic junction, the inflow of chloride ions and induction of an irreversible resting state. The result is flaccid paralysis of affected parasites, followed by their death and/or expulsion.
After topical administration of the product, imidacloprid is rapidly distributed over the animal’s skin within one day of application. It can be found on the body surface throughout the treatment interval. Moxidectin is absorbed through the skin, reaching maximum plasma concentrations approximately 1 to 2 days after treatment in cats and approximately 4 to 9 days after treatment in dogs. Following absorption from the skin, moxidectin is distributed systemically and is slowly eliminated from the plasma as manifested by detectable moxidectin concentrations in plasma throughout the treatment interval of one month.
Marketing Authorisation Holder (if different from distributor)
Marketing Authorisation Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany
Distributed by
UK: Bayer plc, Animal Health Division, Bayer House, Strawberry Hill, Newbury, Berkshire, RG14 1JA
Ireland: Bayer Ltd, Animal Health Division, The Atrium, Blackthorn Road, Sandyford Ind Est, Dublin 18
Marketing authorisation number
GTIN (Global Trade Item No)
Advocate Spot-on solution for Small Cats and Ferrets (3 Pack)
Advocate Spot-on solution for Small Cats and Ferrets (6 Pack)
Advocate Spot-on solution for Large Cats (3 Pack)
Advocate Spot-on solution for Large Cats (6 Pack)
Advocate Spot-on solution for Small Dogs (3 Pack)
Advocate Spot-on solution for Medium Dogs (3 Pack)
Advocate Spot-on solution for Medium Dogs (6 Pack)
Advocate Spot-on solution for Large Dogs (3 Pack)
Advocate Spot-on solution for Large Dogs (6 Pack)
Advocate Spot-on solution for Extra-large Dogs (3 Pack)
Advocate Spot-on solution for Extra-large Dogs (6 Pack)
Need help or advice? Contact us:
- Landline: 01582 842096
- Mon - Fri: 8:30am - 5:00pm
- Sat: 9:00am - 1:00pm
- Email: support@viovet.co.uk
All prices include VAT where applicable.
Below are some recent questions we've received regarding Advocate Spot-on Solution for Dogs & Cats, including answers from our team.
Prescription
Can I purchase advocate without a prescription please
- Veterinary Advisor
No, I'm afraid not. You must have a prescription from your vet to purchase Advocate. Once you have a prescription we would be very happy to supply you with it.
Safe to use on Shetland Sheepdog or Collie ?
- VioVet Customer Since: February 2017
- From: Kowloon, Hong Kong
Is it Safe to use on Shetland Sheepdog or Collie ?
My baby is a 11 years old female Shetland sheep dog
- Veterinary Advisor
This product contains Moxidectin, a Macrocyclic Lactone, in the same class as Ivermectin. Advocate was tested on Ivermectin sensitive collies at 5 times the recommended dose with no adverse effects so it is unlikely to cause a problem for your dog. However it is important that she doesn't lick it. Please see blurb from the data sheet below:
"When the product is applied in 3 to 4 separate spots in larger dogs, specific care should be taken to prevent the animal licking the application sites. Oral uptake by Collies, Old English Sheepdogs and related breeds or crossbreeds should be prevented.
During treatment with Advocate no other antiparasitic macrocyclic lactone should be administered. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described above. In particular, oral uptake by the recipient and/or other animals in close contact should be prevented.
Ivermectin-sensitive Collie dogs tolerated up to 5 times the recommended dose repeated at monthly intervals without any adverse effects, but the safety of application at weekly intervals has not been investigated in ivermectin-sensitive Collie dogs. When 40% of the unit dose was given orally, severe neurological signs were observed. Oral administration of 10% of the recommended dose produced no adverse effects."
Advocate used but still got a couple of fleas
- VioVet Customer Since: February 2015
- From: Bedfordshire, United Kingdom
I use advocate on my spaniel every month but gave just noticed a couple of fleas on her . Her last treatment was Wednesday and Friday I noticed fleas on her Sunday what do you suggest thanks
- Veterinary Advisor
Advocate is generally very good and should be effective if you have applied it properly. What you might have is a problem with fleas in the house. Fleas can reside in the environment and jump onto your dog. The advocate should kill the fleas once they are on your dog but not instantly hence why you have seen a few on your dog. You should use a flea spray such as Virbac Indorex to treat the house- carpets, furniture, bedding, curtains etc.
Can you get a tablet instead of advocatt spot on
My dog Hates me putting the advocart
On his neck. Is there a tablet that covers the same lung worm ect?
We do also worm him as normal with the tablet for that .
- Non-Executive Director
There is a tablet which acts against the same type of lungworm (Angiostrongylus vasorum) but it is best given more frequently and needs to be prescribed by your vet. You could ask your vet about possibly using Milbemax as an alternative to Advocate, but for most dogs it is not a sensible alternative. For your dog it might make sense though.
Is it really necessary to apply advocate to my puppy every month. I am worried about over medicating him as I take my mini pinscher abroad with me three times a year and have to give him a tablet for worms each time so I can bring him back to the UK. He is a very happy and lively dog but quite skinny for my liking. I hope that's not due to all the poison I am forced to give him. Please advise urgently. Thank you.
- Non-Executive Director
If you travel abroad with your puppy, he is almost certainly at much greater risk if he is not treated with these things, than if he is treated. I understand your concerns about forcing "chemicals" upon him, but they are very thoroughly tested products and have been demonstrated to have no adverse effects when used as recommended. Dogs which are not treated are known to suffer a whole host of adverse effects from various parasites which are controlled very effectively by what you are using. (The tablets is for tapeworms which is just about the only worm not treated by Advocate, so they are good to be used together.) I think you are right to question giving these treatments and it does go against the grain somewhat. However I am sure that on average, treated dogs do significantly better than none treated dogs. On balance, your puppy is better off on treatment. Being underweight can be caused by so many different things, it is very unlikely to have anything to do with parasite treatments.
I don't have a prescription for advocat
Why do I need a prescription for flea and worker?
- Non-Executive Director
If we are posting medication to an address in the UK, we have to follow relevant UK law. For reasons we are not involved in, some medicines are legally classed as POM-V which means a veterinary prescription is needed. We will always aim to follow the law. Please note that some other flea and worm treatments do not need a prescription, though at the moment Advocate seems to be an exceptionally effective and safe product. If in the fullness of time it is proven to be this safe, then its legal classification might be relaxed and it might then be available without prescription. Obviously we would like that very much, but it is not our decision. Usually this only happens after a new product has been used widely for a few years to allow time for a full assessment to be made. Advocate is still newer than many of the other products.
My springer/cocker seems to be very subject to ticks at the moment. Is this effective on ticks? I can't see any specific mention of it.
- Non-Executive Director
Advocate is not effective against ticks. (It is a great product and very effective against most parasites, but not against ticks or tapeworms.) There are a number of other treatments for ticks. You can use Frontline Spot-on or a Scalibor collar (the latter probably more effective, both are non-prescription). There are a number of prescription products for ticks, your vet would have to advise you on these. I would suggest the collar to use along with Advocate.
- VioVet Customer Since: October 2014
- From: Essex, United Kingdom
Hi what can I use to treat a 6 week old puppy that has mites
- Non-Executive Director
The safest thing to do is to wait until the puppy is 7 weeks of age, then treat with Advocate. If the mite problem is too bad for that and the diagnosis is definite then your vet might direct you to use Advocate at 6 weeks of age, or try a different product such as Stronghold (which can be used from 6 weeks of age anyway).
Advocate wormer
Can you tell me how long it takes to kill and pass worms after Advocate spot on treatment for my dog.
- Non-Executive Director
I would expect most worms to be killed within 24 hours. However most of them will be digested, rather than expelled, so you would not expect to see any passed in a recognisable state. (Some old fashioned wormers worked partly through getting the entire gut contents to pass out very quickly, worms and all. This made them obvious to see, but is not actually as good for the dog or cat.)
Advocate and worming
- VioVet Customer Since: February 2012
- From: East Riding of Yorkshire, United Kingdom
Hi if I give my cat advocate do I need an additional wormer? Of so for which type of worms- my puppy has had advocate at vets and they advised she needs a tapeworm ing tablet at 12 weeks. I use fibrospot and dronal at the moment
- Non-Executive Director
Advocate covers all worms apart from tapeworms. It also covers for fleas, so you do not need the Fiprospot if you continue with Advocate. Drontal does cover for tapeworms as well as most other worms. If you want a treatment just for tapeworms then Droncit is the one I would recommend (a tablet or spot-on is available).
Call us
Customer Services
VioVet Ltd, 53 Bilton Way , Luton , Beds , LU1 1UU
Royal College of Veterinary Surgeons registered premises 7020333
Company no: 7693671, registered in England and Wales.
A subsidiary of Pethealth Inc, a Fairfax Company.
Medication dispensed under the control of Sophie Wilkinson BVetMed MRCVS (RCVS number: 7011148)
Hjerteorm -behandling med Advocate? <>
Men jeg kan huske, at jeg har læst et eller andet sted at Advocate kun tager larverne og hverken voksne orm eller æg.
Det tager hvis nærmest alt
Sally er nu dryppet med Advocate og indtilvidere er der ingen allergisk reaktion. Krydser fingre for at behandlingen virker..
Jeg fik hende testet både for hjerte/lungeorm og flåtrelateret sygdomme. Hun havde udslag på anaplasmose -men en yderligere prøve viste, at sygdommen ikke var aktiv og det heldigvis kun var antistofferne, der gav udslaget.
Jeg troede derfor, at hendes symptomer tilbage i efteråret skydes hormoner og har efterfølgende talt meget med dyrlægen omkring sterilisering -derfor fik jeg taget blodprøven i mandags for at få en indikation om hun kan tåle narkose.
Bayer Advocate for demodex mange?
I cant wait to start using it and see if it`s going to cure the Demodex. I hope before long it will be avaliable in the US.
Trending Now
HEARTWORM PREVENTION. After topical application, Moxidectin is distributed systemically and with monthly use will prevent heartworm infection in both dogs and cats.
TREATMENT, PROTECTION AND PREVENTION OF GASTROINTESTINAL WORMS. Advocate's unsurpassed efficacy against adult, immature and L4 larval stages assures protection against environmental contamination and prevents reinfestation of the pet.
TREATMENT AND CONTROL OF GENERALISED DEMODICOSIS. Monthly application of Advocate for 2 to 4 treatments is highly effective in the treatment of generalised demodicosis in dogs.
CONTROL OF SARCOPTIC MANGE MITE. Advocate has been shown to eliminate 100% of sarcoptic mites after a single dose.
CONTROL OF EAR MITES. For the treatment of ear mites, Advocate is highly effective as a single dose.
CONTROL OF LICE. Applied monthly, Advocate will control lice.
100 g/L Imidacloprid, 25 g/L Moxidectin
Has anyone used Advocate by bayer in the treatment for Demodex mange? Its used the same as Advantage and it`s for fleas, ticks, ear mites, different manges. I came across this on the web and have called many vets in my area and none of them are carrying it. I would love to know if anyone has used this for mange and did it cure it. My vet said he would check on it this week to see if he could get it. Thanks
Update: My Vet.. called me back and said that Advocate is only avaliable in Canada. Guess I will never know if it will work for curing my dogs Demodex
Update 2: Thanks you all to the ones who answered my question. I was able to purchase this at
I cant wait to start using it and see if it`s going to cure the Demodex. I hope before long it will be avaliable in the US.
Follow 8 answers
Report Abuse
Additional Details
If you believe your intellectual property has been infringed and would like to file a complaint, please see our Copyright/IP Policy
Report Abuse
Additional Details
If you believe your intellectual property has been infringed and would like to file a complaint, please see our Copyright/IP Policy
Report Abuse
Additional Details
If you believe your intellectual property has been infringed and would like to file a complaint, please see our Copyright/IP Policy
Комментариев нет:
Отправить комментарий